C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway
@article{Sawin2000CEL, title={C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway}, author={E. R. Sawin and R. Ranganathan and H. Horvitz}, journal={Neuron}, year={2000}, volume={26}, pages={619-631} }
Caenorhabditis elegans modulates its locomotory rate in response to its food, bacteria, in two ways. First, well-fed wild-type animals move more slowly in the presence of bacteria than in the absence of bacteria. This basal slowing response is mediated by a dopamine-containing neural circuit that senses a mechanical attribute of bacteria and may be an adaptive mechanism that increases the amount of time animals spend in the presence of food. Second, food-deprived wild-type animals, when… CONTINUE READING
794 Citations
A comparison of experience-dependent locomotory behaviors and biogenic amine neurons in nematode relatives of Caenorhabditis elegans
- Biology, Medicine
- BMC Neuroscience
- 2009
- 30
- PDF
Dopamine Mediates Context-Dependent Modulation of Sensory Plasticity in C. elegans
- Biology, Medicine
- Neuron
- 2007
- 133
- Highly Influenced
- PDF
Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans
- Biology, Medicine
- Nature communications
- 2017
- 27
Behavioral adaptation in C. elegans produced by antipsychotic drugs requires serotonin and is associated with calcium signaling and calcineurin inhibition
- Biology, Medicine
- Neuroscience Research
- 2009
- 22
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2004
- 209
- PDF
Food sensitizes C. elegans avoidance behaviours through acute dopamine signalling
- Biology, Medicine
- The EMBO journal
- 2011
- 117
- Highly Influenced
- PDF
Antagonistic Serotonergic and Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior in Caenorhabditis elegans
- Medicine, Biology
- The Journal of Neuroscience
- 2017
- 27
- PDF
References
SHOWING 1-10 OF 125 REFERENCES
A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans
- Biology, Medicine
- Nature
- 1995
- 298
- PDF
Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans
- Biology, Medicine
- Science
- 1995
- 307
The role of a modulatory neuron in feeding and satiation in Aplysia: effects of lesioning of the serotonergic metacerebral cells
- Biology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1989
- 119
- PDF
Regulation of a periodic motor program in C. elegans
- Biology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1994
- 133
- PDF
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
- Biology, Medicine
- Nature
- 2000
- 547
Caenorhabditis elegans: A new model system for the study of learning and memory
- Psychology, Medicine
- Behavioural Brain Research
- 1990
- 239
Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.
- Biology, Medicine
- The Journal of experimental zoology
- 1990
- 326
Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
- Biology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1993
- 254
- Highly Influential
- PDF
Environmental signals modulate olfactory acuity, discrimination, and memory in Caenorhabditis elegans.
- Biology, Medicine
- Learning & memory
- 1997
- 102
- PDF
Mutations in the dopa decarboxylase gene affect learning in Drosophila.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1984
- 156
- PDF