C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations.

@article{Hudson2006CEK,
  title={C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations.},
  author={Martin L Hudson and Tarja Inkeri Kinnunen and Hediye Nese Cinar and Andrew D. Chisholm},
  journal={Developmental biology},
  year={2006},
  volume={294 2},
  pages={352-65}
}
The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the… CONTINUE READING

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