C. elegans Enabled Exhibits Novel Interactions with N-WASP, Abl, and Cell-Cell Junctions

@inproceedings{Sheffield2007CEE,
  title={C. elegans Enabled Exhibits Novel Interactions with N-WASP, Abl, and Cell-Cell Junctions},
  author={Mark Sheffield and Timothy Loveless and Jeff Hardin and Jonathan Pettitt},
  booktitle={Current Biology},
  year={2007}
}
Ena/VASP proteins are associated with cell-cell junctions in cultured mammalian cells [1] and Drosophila epithelia [2, 3], but they have only been extensively studied at the leading edges of migratory fibroblasts, where they modulate the protrusion of the leading edge [4]. They act by regulating actin-filament geometry, antagonizing the effects of actin-capping protein [5]. Embryos lacking the C. elegans Ena/VASP, UNC-34, display subtle defects in the leading edges of migrating epidermal cells… CONTINUE READING

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