C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

@article{Epstein2001CEE,
  title={C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation},
  author={Andrew C.R. Epstein and Jonathan Gleadle and Luke A. McNeill and Kirsty S. Hewitson and John F. O'Rourke and David R Mole and Mridul Mukherji and Eric Metzen and Michael I. Wilson and Anu Dhanda and Y A Tian and Norma Masson and Donald L. Hamilton and Panu Jaakkola and Robert J. Barstead and Jonathan Hodgkin and Patrick Henry Maxwell and Christopher W Pugh and Christopher J. Schofield and Peter J Ratcliffe},
  journal={Cell},
  year={2001},
  volume={107},
  pages={43-54}
}
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets HIF-alpha subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Here, we define a conserved HIF-VHL-prolyl hydroxylase pathway in C. elegans, and use a genetic approach to identify EGL-9 as a dioxygenase that regulates HIF by prolyl hydroxylation. In… CONTINUE READING
Highly Influential
This paper has highly influenced 88 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
1,095 Extracted Citations
36 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 1,095 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 36 references

Chemical cosubstrate rescue of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease

  • M. Mukherji, N. J. Kershaw, +4 authors M. D. Lloyd
  • Chem. Comm. 11, 972–973.
  • 2001
Highly Influential
6 Excerpts

Independent function of two destruction domains in mon, E.I

  • N. Masson, C. Willam, +7 authors SoloP.J
  • EMBO J
  • 2001
Highly Influential
14 Excerpts

Structural origins of the selectivity of the G.A

  • Z. H. Zhang, J. S. Ren, +8 authors C. J. Schofield
  • Nat. Struct. Biol. Res
  • 2000
Highly Influential
4 Excerpts

Mammalian oxygen sensing , signalling and their protein disulfide isomerase subunit

  • R. H. Wenger
  • Matrix Biol .
  • 2000
Highly Influential
3 Excerpts

Regulation studies on 2-oxoglutarate-dependent oxygenases

  • L. E. Huang, J. Gu, M. Schau, H. F. Bunn
  • 1998
Highly Influential
6 Excerpts

How do cells sense oxygen

  • P. H. Maxwell, M. S. Wiesener, +9 authors H. F. Bunn
  • Nature 399,
  • 2001
1 Excerpt

Similar Papers

Loading similar papers…