C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.

@article{Buettner2013CED,
  title={C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.},
  author={Falk F R Buettner and Angel Ashikov and Birgit Tiemann and Ludwig Lehle and Hans Bakker},
  journal={Molecular cell},
  year={2013},
  volume={50 2},
  pages={
          295-302
        }
}
Among the different types of protein glycosylation, C-mannosylation of tryptophan residues stands out because of the unique linkage formed between sugar and protein. Instead of the typical O- or N-glycosidic linkage, a C-C bond is used for attachment of a single mannose. C-mannose is characteristically found in thrombospondin type 1 repeats and in the WSXWS motif of type I cytokine receptors. The genetic base of the enzymatic activity catalyzing C-mannosylation was not known. Here we… CONTINUE READING
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