C. Genetics of Man Enzyme polymorphisms in man

@article{Harris1966CGO,
  title={C. Genetics of Man Enzyme polymorphisms in man},
  author={Harry Harris},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1966},
  volume={164},
  pages={298 - 310}
}
  • H. Harris
  • Published 1966
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
There are a large number of different enzymes synthesized in the human organism, and many of these probably contain more than one structurally distinct polypeptide chain. If current theories about genes and proteins are correct we must suppose that the primary structure of each of these different polypeptides is determined by a separate gene locus, and that there are probably also other loci which are specifically concerned with regulating the rate of synthesis of particular polypeptides or… Expand
Protein polymorphism in man.
  • H. Harris
  • Biology, Medicine
  • Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie
  • 1971
Perhaps the most important contribution that molecular biology has made to population genetics has been in the demonstration of the extraordinary number of alleles wish different properties which mayExpand
Genetically determined polymorphisms of erythrocyte enzymes in man.
  • D. Hopkinson
  • Biology, Medicine
  • Advances in clinical chemistry
  • 1968
Publisher Summary This chapter deals with commonly occurring genetically determined variations of the enzymes found in human red cells and considers enzyme variants of many different kinds ofExpand
Nucleotide sequence homology within the genome of Drosophila melanogaster.
TLDR
The determination patterns and rates of divergence of genes in related organisms affords a comparison with phyletic relationships determined by phenotypic traits and an approach to the detection of base sequence relationships within a genome utilizes techniques of specific duplex reactions of polynucleotides. Expand
Isoenzymes in genetics and evolution
TLDR
The usefulness of isoenzymes as genetic markers is illustrated in the following experiment devised to test the Lyon Hypothesis, which was in its own right an important advance in the understanding of genetic regulation. Expand
Review Lecture Genes and isozymes
  • H. Harris
  • Biology
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
  • 1969
TLDR
The central concept that has emerged is that the primary amino acid sequence of each of the structurally distinct polypeptide chains that occur in the vast array of different enzymes that an organism forms, is encoded in the sequence of base pairs in the DNA of a corresponding gene. Expand
Extraordinary Incidence of Electrophoretically Silent Genetic Polymorphisms
TLDR
It is shown that among 3×2×440 = 2,640 allele products, the incidence of different kinds of common variant alleles was 5/2,640, and the variation represented by electrophoretically detected polymorphism is comparatively restricted. Expand
GENETICS OF ESTERASES IN MAN
  • N. Simpson
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1968
TLDR
The genetics of esterases in man to be described has been studied by both the "mass screening” and the “unusual pharmacological response” methods. Expand
Low nucleotide diversity in man.
TLDR
The nucleotide diversity in humans is very low, probably due to a relatively small long-term effective population size rather than any severe bottleneck during human evolution. Expand
Ecological Factors and the Variability of Gene-Pools in Drosophila
TLDR
The main purposes of the paper were to point out the comparatively large fraction of deaths in man that might reasonably be attributed to genetic causes and to consider the frequencies, mutation rates, dominance relations, and other characteristics of the genes involved together with the effect of cultural factors upon the total burden or load of such genes. Expand
Allozyme polymorphism in Drosophila
TLDR
The genetic differentiation as observed through allozyme or isozyme variation affords an important parameter in evaluating the phylogenetic relationships between different species of Drosophila and also for discussing the adaptive significance of allo enzyme polymorphisms. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 13 REFERENCES
Quantitative Differences and Gene Dosage in the Human Red Cell Acid Phosphatase Polymorphism
TLDR
The relation between the observed phenotypes and the postulated genotypes is indicated, and the frequencies with which the various phenotypes have been observed in a random sample of English adults are given. Expand
On distribution and inheritance of atypical forms of human serum cholinesterase, as indicated by dibucaine numbers.
  • W. Kalow, N. Staron
  • Biology, Medicine
  • Canadian journal of biochemistry and physiology
  • 1957
TLDR
Most observations on the inheritance of DN can be explained by the presence of two autosomal allelic genes without dominance, each gene causing the formation of one of the two types of enzyme. Expand
Genetical studies on a new variant of serum cholinesterase detected by electrophoresis
TLDR
At least four distinct zones with properties of serum cholinesterase (pseudocholinestersterase) may be demonstrated by starch gel electrophoresis of normal serum or plasma, and it seems likely that they may represent a series of polymers of increasing molecular weight C1 < C3 < C4. Expand
HEREDITARY RED CELL TRAITS AND MALARIA.
  • A. Motulsky
  • Biology, Medicine
  • The American journal of tropical medicine and hygiene
  • 1964
TLDR
If a genetic trait protects against malaria but also has harmful effects and causes illness or diminished fertility, an equilibrium gene frequency will be reached at which the beneficial and harmful effects of such a gene balance each other. Expand
Acid Phosphatases of Human Red Cells: Predicted Phenotype Conforms to a Genetic Hypothesis
Analysis of data from 80 families and 369 unrelated individuals confirms the hypothesis that human red cell acid phosphatase phenotypes are determined by three codominant alleles at a singleExpand
Human Red-cell Phosphogluconate Dehydrogenases
TLDR
A procedure for the detection of human red-cell 6-phosphogluconate dehydrogenase (6-PGD) by starch-gel electrophoresis, and the existence of this enzyme in different genetically determined forms is reported. Expand
GENETICAL STUDIES ON HUMAN RED CELL ACID PHOSPHATASE.
Phosphoglucomutase Polymorphism in Man
...
1
2
...