C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts

Abstract

Piwi Argonautes and Piwi-interacting RNAs (piRNAs) mediate genome defense by targeting transposons. However, many piRNA species lack obvious sequence complementarity to transposons or other loci; only one C. elegans transposon is a known piRNA target. Here, we show that, in mutants lacking the Piwi Argonaute PRG-1 (and consequently its associated piRNAs/21U… (More)
DOI: 10.1016/j.cell.2012.06.016

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