C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.

  title={C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.},
  author={Philip R McQuary and Chen-Yu Liao and Jessica Chang and Caroline Kumsta and Xingyu She and Andrew E. Davis and Chu-Chiao Chu and Sara Gelino and Rafael L. Gomez-Amaro and Michael Petrascheck and Laurence M. Brill and Warren C. Ladiges and Brian Kennedy and Malene Hansen},
  journal={Cell reports},
  volume={14 9},
Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegans mutants compared to wild-type animals. We identified the arginine kinase ARGK-1 as the most significantly enriched protein in rsks-1/S6K mutants. ARGK-1 is an ortholog of mammalian creatine kinase, which maintains cellular ATP levels. We found that argk… CONTINUE READING
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