C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and – independent pathways

C-type natriuretic peptide (CNP) has recently been identified as an important anabolic regulator of endochondral bone growth, but the molecular mechanisms mediating its effects are not completely understood. We demonstrate in a tibia organ culture system that pharmacological inhibition of p38 blocks the anabolic effects of CNP. We further show that CNP… CONTINUE READING

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