C-type natriuretic peptide inhibits mesangial cell proliferation and matrix accumulation in vivo.

@article{CanaanKuehl1998CtypeNP,
  title={C-type natriuretic peptide inhibits mesangial cell proliferation and matrix accumulation in vivo.},
  author={Sima Canaan-Kuehl and Tammo Ostendorf and Kaitlin Zander and Karl Koch and Jurgen Floege},
  journal={Kidney international},
  year={1998},
  volume={53 5},
  pages={1143-51}
}
Local C-type natriuretic peptide (CNP) production and CNP receptor expression have been demonstrated in glomeruli. However, the glomerular (patho-)physiological functions of CNP are largely unknown. We therefore investigated the effects of CNP on mesangial cell proliferation and matrix accumulation in the rat mesangioproliferative anti-Thy 1.1 model. Over seven days rats received a continuous infusion (1 microgram/kg/min) of either CNP (N = 6), an irrelevant control peptide (N = 3) or buffer… CONTINUE READING
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