C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells.

@article{Porter1992CtypeNP,
  title={C-type natriuretic peptide inhibits growth factor-dependent DNA synthesis in smooth muscle cells.},
  author={John W. Porter and Rob D. Catalano and Glenn A. McEnroe and John A. Lewicki and Andrew A. Protter},
  journal={The American journal of physiology},
  year={1992},
  volume={263 5 Pt 1},
  pages={C1001-6}
}
We have examined the ability of C-type natriuretic peptide (CNP) to interact with guanylate cyclase-coupled natriuretic peptide receptors by measuring its ability to stimulate intracellular guanosine 3',5'-cyclic monophosphate (cGMP) accumulation in cultured bovine aortic endothelial (BAE) and bovine aortic smooth muscle (BASM) cells. Our experiments indicate that CNP is unable to stimulate the production of cGMP in BAE cells, whereas both atrial natriuretic peptide (ANP) and brain natriuretic… CONTINUE READING

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