C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.

@article{Gringhuis2007CtypeLD,
  title={C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.},
  author={Sonja I. Gringhuis and Jeroen den Dunnen and Manja Litjens and Bert van het Hof and Yvette van Kooyk and Teunis B. Geijtenbeek},
  journal={Immunity},
  year={2007},
  volume={26 5},
  pages={605-16}
}
Adaptive immune responses by dendritic cells (DCs) are critically controlled by Toll-like receptor (TLR) function. Little is known about modulation of TLR-specific signaling by other pathogen receptors. Here, we have identified a molecular signaling pathway induced by the C-type lectin DC-SIGN that modulates TLR signaling at the level of the transcription factor NF-kappaB. We demonstrated that pathogens trigger DC-SIGN on human DCs to activate the serine and threonine kinase Raf-1, which… CONTINUE READING
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