C-type inactivation of voltage-gated K+ channels: Pore constriction or dilation?

  title={C-type inactivation of voltage-gated K+ channels: Pore constriction or dilation?},
  author={Toshinori Hoshi and Clay Armstrong},
  booktitle={The Journal of general physiology},
K + channels have many timing and control functions throughout the body, especially in the nervous system and heart. These vital functions are made possible by several types of " gates " that govern ion flow through the channels (Yellen, 1998). K V channels (K + selective, voltage activated), exemplified by Drosophila melanogaster Shaker channels, are homotetramers, with each subunit containing six transmembrane helices (TMS1–TMS6); they have an internally located gate (here called the V-gate… CONTINUE READING
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