C terminus of the P2X7 receptor: treasure hunting

  title={C terminus of the P2X7 receptor: treasure hunting},
  author={Helio Miranda Costa-Junior and Fl{\'a}via Sarmento Vieira and Robson Coutinho-Silva},
  journal={Purinergic Signalling},
P2X receptor (P2XR) is a family of the ATP-gated ion channel family and can permeabilize the plasma membrane to small cations such as potassium, sodium, and calcium, resulting in cellular depolarization. There are seven P2XR that have been described and cloned, with 45% identity in amino acid sequence. Each P2X receptors has two transmembrane domains that are separated by an extracellular loop and an intracellular N and C terminus. Unlike the other P2X receptors, the P2X7R has a larger C… CONTINUE READING


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