C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation.

@article{Olsen2010CterminallyTD,
  title={C-terminally truncated derivatives of Escherichia coli Hfq are proficient in riboregulation.},
  author={Anders Steno Olsen and Jakob M\oller-Jensen and Richard G Brennan and P. Valentin-Hansen},
  journal={Journal of molecular biology},
  year={2010},
  volume={404 2},
  pages={173-82}
}
The prokaryotic Sm-like protein Hfq plays an essential role in the stability and function of trans-encoded small regulatory RNAs in enterobacteria that function in posttranscriptional control by base-pairing with cognate target mRNAs. Hfq associates with both regulatory RNA and target RNA, and its interaction promotes annealing. So far, mutational and structural studies have established that Escherichia coli Hfq contains two separate RNA binding sites that are part of the conserved N-terminal… CONTINUE READING