C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae

@article{KochnevaPervukhova1998CterminalTO,
  title={C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [PSI+] determinant in Saccharomyces cerevisiae},
  author={Natalia V. Kochneva-Pervukhova and A. I. Poznyakovski and Vladlmir N. Smirnov and Michael D. Ter-Avanesyan},
  journal={Current Genetics},
  year={1998},
  volume={34},
  pages={146-151}
}
The yeast non-Mendelian [PSI + ] determinant is presumed to be the manifestation of the aggregated prion-like state of the Sup35 protein. Plasmid-mediated amplification of the SUP35 gene greatly increases the frequency of Sup35p transition to this prion-like state. Here we show that the 3′-deletions of plasmid SUP35, leading to the C-terminal truncation of Sup35p, further increase the frequency of [PSI + ] induction despite a marked decrease in Sup35p expression levels. The data suggest that… CONTINUE READING
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