C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells.

@article{Martnez1997CterminalPH,
  title={C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells.},
  author={Mar Mart{\'i}nez and Adolfo Garcia-Oca{\~n}a and Montse Arag{\"u}{\'e}s S{\'a}nchez and Sonia Medina and T del Campo and Alexandre Valin and M. J. S{\'a}nchez-Cabezudo and Pedro Esbrit},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1997},
  volume={12 5},
  pages={778-85}
}
Parathyroid hormone-related protein (PTHrP) is synthesized by osteoblasts, although its local role in bone is not completely understood. The C-terminal (107-111) region of PTHrP seems to be a potent inhibitor of osteoblastic bone resorption. We studied the effect of this PTHrP domain on the proliferation and synthesis of osteoblastic markers in osteoblast-like cells from adult human bone. We found that the human (h)PTHrP(107-139) fragment, between 10 fM and 10 nM, inhibited 3H-thymidine… CONTINUE READING