C-terminal octapeptide of cholecystokinin decreases food intake in obese men.

@article{PiSunyer1982CterminalOO,
  title={C-terminal octapeptide of cholecystokinin decreases food intake in obese men.},
  author={Xavier Pi-Sunyer and Harry R. Kissileff and Jennifer Thornton and Gerard P Smith},
  journal={Physiology & behavior},
  year={1982},
  volume={29 4},
  pages={627-30}
}
Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of eating. No overt side effects were reported or observed. This is the first report of the satiety effect of CCK-8 in obese humans and it suggests that the therapeutic potential of CCK-8 for… CONTINUE READING