C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor

@article{Krstenansky1990CterminalMO,
  title={C-terminal modifications of neuropeptide Y and its analogs leading to selectivity for the mouse brain receptor over the porcine spleen receptor},
  author={John L Krstenansky and Thomas J. Owen and Marguerite H. Payne and S. A. Shatzer and Stephen H. Buck},
  journal={Neuropeptides},
  year={1990},
  volume={17},
  pages={117-120}
}
Design of the Y1-receptor-selective cyclic peptide based on the C-terminal sequence of neuropeptide Y.
TLDR
Four cyclic peptides which are mimics of the C-terminal region of human neuropeptide Y (NPY) on the basis of the structural model of NPY exhibited significantly higher affinity for the Y1-receptor than the corresponding C- terminate linear fragment, NPY Ac-28-36.
Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226
TLDR
It is concluded that Y1 receptors exclusively, mediate the NPY‐induced contraction in human cerebral arteries and BIBP 3226 is a potent and competitive antagonist of this Y1‐mediated vasoconstriction.
Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets?
TLDR
It has been appreciated that NPY may also be an important messenger in its own right , perhaps particularly in the brain, where NP Y has been frequently used to study cotransmission, particularly in its relation to the "classical" neurotransmitter norepinephrine.
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TLDR
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TLDR
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