C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking.

@article{Chen2007CterminalMI,
  title={C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking.},
  author={Zi-Wei Chen and C S Chang and Tarek A Leil and Richard W. Olsen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 25},
  pages={6655-63}
}
We investigated the ubiquitin-like modification of GABA(A) receptor-associated protein (GABARAP) and its function. A fusion protein of GABARAP with v5 in the N terminus and myc in the C terminus was expressed in rat cultured hippocampal neurons and PC12 cells. Western blotting with antibodies to v5 and myc revealed that the C terminus of GABARAP was cleaved off. Cleavage was blocked by mutating the C-terminal Gly116 to Ala, suggesting that G116 is required for the processing. Unlike ubiquitin… CONTINUE READING
18 Extracted Citations
52 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 18 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…