C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.

@article{Gong2016CterminalDO,
  title={C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.},
  author={Jihong Gong and Y Lai and Xiaohong Li and Mengxian Wang and Jeremy Leitz and Yachong Hu and Yunxiang Zhang and Ucheor B Choi and Daniel J. Cipriano and Richard A Pfuetzner and Thomas C S{\"u}dhof and Xiaofei Yang and Axel T Brunger and Jiajie Diao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 47},
  pages={E7590-E7599}
}
In presynaptic nerve terminals, complexin regulates spontaneous "mini" neurotransmitter release and activates Ca2+-triggered synchronized neurotransmitter release. We studied the role of the C-terminal domain of mammalian complexin in these processes using single-particle optical imaging and electrophysiology. The C-terminal domain is important for regulating spontaneous release in neuronal cultures and suppressing Ca2+-independent fusion in vitro, but it is not essential for evoked release in… CONTINUE READING
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References

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Study on the interaction of cationic lipids with bovine serum albumin.

The journal of physical chemistry. B • 2010
View 10 Excerpts
Highly Influenced

SNAREpins:Minimalmachinery formembrane fusion. Cell 92(6):759–772

T Weber
1998
View 10 Excerpts
Highly Influenced

N-terminal domain of complexin independently activates calcium-triggered fusion.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 3 Excerpts

Pre - incubation of t - SNAREs with complexin I increases content - mixing efficiency

E Neher
Biochemistry • 2016

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