C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila.

@article{Fang2006CterminalbindingPD,
  title={C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila.},
  author={Ming Fang and Jiong Li and Timothy A. Blauwkamp and Chandan Bhambhani and Nathan Campbell and Ken M Cadigan},
  journal={The EMBO journal},
  year={2006},
  volume={25 12},
  pages={2735-45}
}
Regulation of Wnt transcriptional targets is thought to occur by a transcriptional switch. In the absence of Wnt signaling, sequence-specific DNA-binding proteins of the TCF family repress Wnt target genes. Upon Wnt stimulation, stabilized beta-catenin binds to TCFs, converting them into transcriptional activators. C-terminal-binding protein (CtBP) is a transcriptional corepressor that has been reported to inhibit Wnt signaling by binding to TCFs or by preventing beta-catenin from binding to… CONTINUE READING

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