C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase.

@article{Xu2007CreactivePS,
  title={C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase.},
  author={Jin-wen Xu and Ikuo Morita and Katsumi Ikeda and Tomohiro Miki and Yukio Yamori},
  journal={Molecular endocrinology},
  year={2007},
  volume={21 2},
  pages={564-73}
}
Although few epidemiological studies have demonstrated that C-reactive protein (CRP) is related to insulin resistance, no study to date has examined the molecular mechanism. Here, we show that recombinant CRP attenuates insulin signaling through the regulation of spleen tyrosine kinase (Syk) on small G-protein RhoA, jun N-terminal kinase (JNK) MAPK, insulin receptor substrate-1 (IRS-1), and endothelial nitric oxide synthase in vascular endothelial cells. Recombinant CRP suppressed insulin… CONTINUE READING