C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.

Abstract

INTRODUCTION Microbial translocation has been implicated as a contributing factor to the heightened immune activation observed during HIV-1 disease progression. When examined in a longitudinal study of HIV-1 seroconverters in Rakai, Uganda, microbial translocation was not associated with HIV-1 disease progression. However, the role of general immune activation in HIV disease progression in this population was not fully examined. METHODS Longitudinal serum samples of HIV-1 seroconverters in three HIV-1 disease progression groups [long-term nonprogressors (LTNP), standard progressors (SP), and rapid progressors (RP)] from Rakai, Uganda, were tested for levels of C-reactive protein (CRP), a marker for immune activation. RESULTS CRP levels significantly increased in the SP group (P < 0.0001) but not in the RP group or the LTNP group. CRP levels during the first year post-HIV seroconversion in the RP group were significantly higher than those observed in the LTNP group (P < 0.05). For the entire population, CRP levels negatively correlated with lipopolysaccharide levels (P < 0.05) and were not associated with endotoxin antibody levels. CONCLUSIONS This study suggests that in this population, increased immune activation is significantly associated with HIV-1 disease progression but not microbial translocation.

DOI: 10.1097/QAI.0b013e3181e0cdea

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Cite this paper

@article{Redd2010CreactivePL, title={C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation.}, author={Andrew Redd and Kevin P Eaton and Xiangrong Kong and Oliver Laeyendecker and Tom Lutalo and Maria J Wawer and Ronald Henry Gray and David M Serwadda and Thomas C. Quinn}, journal={Journal of acquired immune deficiency syndromes}, year={2010}, volume={54 5}, pages={556-9} }