C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.

@article{Tanigaki2009CreactivePI,
  title={C-reactive protein inhibits insulin activation of endothelial nitric oxide synthase via the immunoreceptor tyrosine-based inhibition motif of FcgammaRIIB and SHIP-1.},
  author={Keiji Tanigaki and Chieko Mineo and Ivan S. Yuhanna and Ken L. Chambliss and Michael J. Quon and Ezio Bonvini and Philip W. Shaul},
  journal={Circulation research},
  year={2009},
  volume={104 11},
  pages={1275-82}
}
Insulin promotes the cardiovascular protective functions of the endothelium including NO production by endothelial NO synthase (eNOS), which it stimulates via Akt kinase which phosphorylates eNOS Ser1179. C-reactive protein (CRP) is an acute-phase reactant that is positively correlated with cardiovascular disease risk in patients with type 2 diabetes. We previously showed that CRP inhibits eNOS activation by insulin by blunting Ser1179 phosphorylation. We now elucidate the underlying molecular… CONTINUE READING

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