C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids.

@article{Chang2002CreactivePB,
  title={C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids.},
  author={M K Chang and Christoph J. Binder and Michael Torzewski and Joseph L. Witztum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 20},
  pages={13043-8}
}
C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms. CRP elevation also is a major risk factor for cardiovascular disease. We previously demonstrated that EO6, an antioxidized LDL autoantibody, was a T15 clono-specific anti-PC antibody and specifically binds to PC on oxidized phosphatidylcholine (PtC) but not on native PtC… CONTINUE READING
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