C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes.

@article{Khan2006CphycocyaninAD,
  title={C-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes.},
  author={Mahmood Khan and Saradhadevi Varadharaj and Jagdish Chandra Shobha and Madireddi Umamaheswara Rao Naidu and Narasimham L. Parinandi and Vijay Kumar Kutala and Periannan Kuppusamy},
  journal={Journal of cardiovascular pharmacology},
  year={2006},
  volume={47 1},
  pages={9-20}
}
Doxorubicin (DOX), a potent antineoplastic agent, poses limitations for its therapeutic use due to the associated risk of developing cardiomyopathy and congestive heart failure. The cardiotoxicity of doxorubicin is associated with oxidative stress and apoptosis. We have recently shown that Spirulina, a blue-green alga with potent antioxidant properties, offered significant protection against doxorubicin-induced cardiotoxicity in mice. The aim of the present study was to establish the possible… CONTINUE READING
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