C-peptide replacement improves weight gain and renal function in diabetic rats.

  title={C-peptide replacement improves weight gain and renal function in diabetic rats.},
  author={Laurie Rebsomen and S{\'e}verine Pitel and Farid Boubred and Christophe Buffat and J M Feuerstein and D Raccah and Ph Vague and Michel Tsimaratos},
  journal={Diabetes & metabolism},
  volume={32 3},
AIM Recent experimental and clinical data suggest that C-peptide replacement during type 1 diabetes exerts beneficial effects on diabetic nephropathy. The aim of this study was to determine if physiological C-peptide administration in replacement dose during 28 days had beneficial effects on metabolic status and renal functions in type-1 diabetic rats. METHODS Four groups of rats were investigated: a non diabetic group treated with buffer (C group, n=6), three streptozotocin diabetic-induced… CONTINUE READING

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