C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells.

@article{Wang2016CpeptideEA,
  title={C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells.},
  author={Junxia Wang and Yanning Li and Mingzhi Xu and Dandan Li and Yu Wang and Jinsheng Qi and Kunyu He},
  journal={Experimental and therapeutic medicine},
  year={2016},
  volume={12 6},
  pages={4142-4146}
}
Insufficient matrix metalloproteinase (MMP)-9 and MMP-2 is considered to be a contributor of extracellular matrix (ECM) accumulation in diabetic nephropathy (DN). C-peptide can reverse fibrosis, thus exerting a beneficial effect on DN. Whether C-peptide induces MMP-9 and MMP-2 to reverse ECM accumulation is not clear. In the present study, in order to… CONTINUE READING