C-myc overexpression and p53 loss cooperate to promote genomic instability

Abstract

p53 monitors genomic integrity at the G1 and G2/M cell cycle checkpoints. Cells lacking p53 may show gene amplification as well as the polyploidy or aneuploidy typical of many tumors. The pathways through which this develops, however, are not well defined. We demonstrate here that the combination of p53 inactivation and c-myc overexpression in diploid cells… (More)
DOI: 10.1038/sj.onc.1202410

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@article{Yin1999CmycOA, title={C-myc overexpression and p53 loss cooperate to promote genomic instability}, author={Xiaoying Yin and Linnette Grove and Nabanita S. Datta and Michael William Long and Edward V. Prochownik}, journal={Oncogene}, year={1999}, volume={18}, pages={1177-1184} }