C-mos, a nuclear marker useful for squamate phylogenetic analysis.

@article{Saint1998CmosAN,
  title={C-mos, a nuclear marker useful for squamate phylogenetic analysis.},
  author={Kathleen M. Saint and Christopher C. Austin and Stephen C. Donnellan and Mark N. Hutchinson},
  journal={Molecular phylogenetics and evolution},
  year={1998},
  volume={10 2},
  pages={
          259-63
        }
}
Phylogenetic reconstruction in molecular systematics has largely been achieved using mitochondrial gene sequences and less frequently sequences of nuclear ribosomal RNA genes. At present few other nuclear genes have been identified that could be used to test these phylogenies. C-mos, a single-copy nuclear oncogene, has been identified as a candidate nuclear marker. Data are presented on the usefulness of c-mos sequences in the phylogenetic analysis of squamate reptile families. We obtained… 

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Multiple copies of coding as well as pseudogene c-mos sequence exist in three lacertid species.

  • M. PavlicevW. Mayer
  • Biology
    Journal of experimental zoology. Part B, Molecular and developmental evolution
  • 2006
Sequence divergence suggests that the duplication and the loss of function occurred in the late Miocene/early Pliocene, i.e., about 5 million years ago, and future studies using c-mos for phylogenetic studies should provide evidence for the orthology of the sequences compared.

The Use of c-mos Nuclear Gene as a Phylogenetic Marker in Tetraonidae Birds

A 480-bp fragment of nuclearc-mos gene was sequenced in nine bird species representing four genera of the family Tetraonidae and data obtained point to a paraphyletic origin of hazel grouse and ruffed grouse.

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Squamate relationships based on C-mos nuclear DNA sequences: increased taxon sampling improves bootstrap support

The authors' analysis supports a robust estimate of relationships within the Iguanidae, and provides independent evidence for rapid speciation within this family.
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