C-kit protein expression in uterine and ovarian mesenchymal tumours.

  title={C-kit protein expression in uterine and ovarian mesenchymal tumours.},
  author={G{\"u}lg{\"u}n Erdogan and Cumhur İbrahim Başsorgun and Hadice Elif Peştereli and Tayy{\"u}p Simsek and Seyda Karaveli},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={115 3},
The protooncogene c-kit encoding transmembrane tyrosine kinase receptor protein plays an important role in the signal transduction pathway that regulates cellular growth and repair. Gene product KIT overexpression has been shown in a number of different neoplasms, particularly in mastocytosis and gastrointestinal stromal tumours (GIST). The morphologic similarity of uterine mesenchymal tumours and GIST, and the presence of KIT protein in normal uterine tissue, suggests that uterine sarcomas may… CONTINUE READING

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