C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression.

@article{Yamazaki1994CkitGI,
  title={C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression.},
  author={Masanori Yamazaki and Tohru Tsujimura and Eiichi Morii and Kouji Isozaki and Hitoshi Onoue and Shosaku Nomura and Yukihiko Kitamura},
  journal={Blood},
  year={1994},
  volume={83 12},
  pages={3509-16}
}
The Wsh is a mutant allele at the W (c-kit) locus of mice, but no significant abnormalities are found at the coding region of the Wsh allele. Since cultured mast cells derived from the spleen of Wsh/Wsh mice do not express messenger RNA (mRNA) of c-kit, we studied the interrelation between the number of mast cells and the magnitude of c-kit mRNA expression in the skin of Wsh/Wsh mice of various ages. The number of mast cells in the skin of Wsh/Wsh embryos of 18 days postcoitum (pc) was… CONTINUE READING
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