C-kit and PDGFRA gene mutations in triple negative breast cancer.

@article{Zhu2014CkitAP,
  title={C-kit and PDGFRA gene mutations in triple negative breast cancer.},
  author={Yun Zhu and Yanli Wang and Bing Guan and Qiu Rao and Jiandong Wang and Henghui Ma and Zhi-hong Zhang and Xiaojun Zhou},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 7},
  pages={4280-5}
}
In this study, we evaluated C-kit immunohistochemical expression and C-kit and platelet derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast cancer. 171 cases were analyzed by immunohistochemical staining for the expression of C-kit and 45 cases, including 10 C-kit negative cases and 35 C-kit positive cases, were performed for C-kit gene mutations in exons 9, 11, 13 and 17 and PDGFRA gene mutations in exons 12 and 18. C-kit expression was detected in 42.1% of… CONTINUE READING
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