C-kit Expression in Germinoma: An Munohistochemistry-based Study

  title={C-kit Expression in Germinoma: An Munohistochemistry-based Study},
  author={Hideo Nakamura and Hideo Takeshima and Keishi Makino and Jun-ichi Kuratsu},
  journal={Journal of Neuro-Oncology},
In our immunohistochemical study of 25 human primary intracranial germinomas and germinomas with syncytiotrophoblastic giant cells (STGC), we stained the same sections for c-kit and placental alkaline phosphatase (PLAP). Immunohistochemical expression was graded using a semi-quantitative scoring system where 3+ = 51–75%, and 4+ = 76–100%. Of the 25 cases, 7 (28%) were graded 3+ and 18 (72%) 4+ for c-kit; 8 (32%) were 3+ or 4+ for PLAP. All 3 cases negative for PLAP-staining were strongly… CONTINUE READING


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