C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure.

@article{Hallahan1995CjunAE,
  title={C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure.},
  author={Dennis E.. Hallahan and Edward James Dunphy and Subbulakshmi Virudachalam and Vikas P Sukhatme and Donald Kufe and Ralph R. Weichselbaum},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 51},
  pages={
          30303-9
        }
}
Exposure of mammalian cells to ionizing radiation results in the induction of the immediate early genes, c-jun and Egr-1, which encode transcription factors implicated in cell growth as well as the cellular response to oxidative stress. We studied the role of these immediate early genes in cell cycle kinetics and cell survival following x-irradiation of clones containing inducible dominant negatives to c-jun and Egr-1. The dominant negative constructs to c-jun (delta 9) and Egr-1 (WT/Egr… CONTINUE READING
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