C-erbB-2 oncoprotein overexpression identifies a subgroup of estrogen receptor positive (ER+) breast cancer patients with poor prognosis.

@article{Pinto2001CerbB2OO,
  title={C-erbB-2 oncoprotein overexpression identifies a subgroup of estrogen receptor positive (ER+) breast cancer patients with poor prognosis.},
  author={Ant{\'o}nio Evaristo Pinto and Saudade P Andr{\'e} and Teresa Pereira and Sonia Nobrega and Jorge Fernando Maxnuck Soares},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2001},
  volume={12 4},
  pages={525-33}
}
PURPOSE To investigate the predictive value of c-erbB-2 oncoprotein expression as compared with established histopathological and cytometric indicators of disease evolution in breast carcinoma. PATIENTS AND METHODS A short-term retrospective study was conducted on a series of 306 breast cancer patients. Classic prognostic factors included tumour size, nodal involvement, histological grading, and hormone receptor status. Flow cytometric DNA ploidy and S-phase fraction (SPF) were also assessed… CONTINUE READING
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