C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.

@article{Kern1994CerbB2EA,
  title={C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.},
  author={Jeffrey A. Kern and Robbert J. C. Slebos and Bert Top and Sjoerd Rodenhuis and Donna J. Lager and Richard A. Robinson and Daniel Weiner and David A Schwartz},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 2},
  pages={516-20}
}
We evaluated the prognostic significance of p185c-erbB-2 expression and ras gene mutations in all patients diagnosed with a pulmonary adenocarcinoma between 1982 and 1985 at the University of Iowa. p185c-erbB-2 expression was detected in 15 cases (34%). A ras gene mutation was found in 16 cases (36%) and all were in codon-12 of K-ras. No N-ras mutations were identified. Both p185c-erbB-2 expression and a K-ras mutation were found only in codon-12 and present in six cases (14%). By univariate… CONTINUE READING