C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors.

@article{Steigerwald2000CTerminalTO,
  title={C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors.},
  author={Frank Steigerwald and Torsten W Schulz and L T Schenker and Mary B. Kennedy and P. H. Seeburg and Georg K{\"o}hr},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 12},
  pages={
          4573-81
        }
}
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional regulation at central excitatory synapses. To examine the role of the C-terminal domain of NR2A in the synaptic localization and function of NR2A-containing NMDA receptors in hippocampal Schaffer collateral-CA1 pyramidal cell synapses, we analyzed mice which express NR2A only in its C-terminally truncated… CONTINUE READING

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