C-Terminal regions of topoisomerase IIα and IIβ determine isoform-specific functioning of the enzymes in vivo

Abstract

Topoisomerase II removes supercoils and catenanes generated during DNA metabolic processes such as transcription and replication. Vertebrate cells express two genetically distinct isoforms (a and b) with similar structures and biochemical activities but different biological roles. Topoisomerase IIa is essential for cell proliferation, whereas topoisomerase… (More)
DOI: 10.1093/nar/gkm102

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