C-Terminal Binding Protein is Involved in Promoting to the Carcinogenesis of Human Glioma

@article{Liu2016CTerminalBP,
  title={C-Terminal Binding Protein is Involved in Promoting to the Carcinogenesis of Human Glioma},
  author={Bo Liu and Gloria Di},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={6121-6132}
}
C-terminal binding protein (CtBP) is responsible for regulating the pathogenesis of a lot of cancer types. However, whether CtBP1/2 is involved in regulating the growth and development of human glioma is still obscure. In the present study presented here, our results firstly reveal that CtBP1/2 deficiency, induced by siRNA interference, disrupts the functional integrity of the MRN complex that is responsible for DNA repair in human glioma cells. The dysfunction of the MRN complex further… CONTINUE READING