C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.

@article{Peng1998CTAK1PK,
  title={C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.},
  author={Cong Peng and Paul R. Graves and Scott Ogg and Richard S Thoma and Matthew J. Byrnes and Zhiqi Wu and Mary T. Stephenson and Helen Piwnica-Worms},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1998},
  volume={9 3},
  pages={
          197-208
        }
}
Cdc25C is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15. Cdc25C is phosphorylated on serine 216 throughout interphase but not during mitosis. Serine 216 phosphorylation mediates the binding of 14-3-3 protein to Cdc25C, and Cdc25C/14-3-3 complexes are present throughout interphase but not during mitosis. Here we report the cloning of a human kinase denoted C-TAK1 (for Cdc twenty-five C associated protein kinase… CONTINUE READING
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