• Corpus ID: 10347445

C-Reactive Protein and its applications in Oral and Maxillofacial Surgery-An Overview

  title={C-Reactive Protein and its applications in Oral and Maxillofacial Surgery-An Overview},
  author={Mohammed Imran and Akshay Shetty and K VivekG. and Adil Shafath and N. Vaibhav},
C-reactive protein (CRP) was discovered by Tillet and Francis in 1930 as a substance in the serum of patients with acute inflammation that reacted with the C polysaccharide of pneumococcus. C-reactive protein (CRP) is an acute phase protein which reflects a measure of the acute phase response. CRP, which is present in only small amounts in healthy individuals, is involved in several processes of the unspecific immunologic defense. The serum levels of CRP raises with infection making it a… 




Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis.

Analysis of infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy suggests that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

C-reactive protein as a marker of infection in critically ill patients.

  • P. PóvoaL. Coelho H. Sabino
  • Medicine
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2005
It was concluded that CRP was a better marker of infection than temperature, however, the combination of CRP and temperature measurements further increased the specificity for infection diagnosis, even in the subgroup of patients with VAP.

C-reactive protein levels: a prognostic marker for patients with head and neck cancer?

The findings do not appear to support a correlation between preoperative CRP levels and development of recurrence or metastases in patients with oral cancer.

C-Reactive Protein and Cardiovascular Diseases

C-reactive protein (CRP) is a unique risk marker and plays a role in the pathogenesis of inflammation and atherosclerosis, and has a predictive value for the development of peripheral vascular disease, restenosis following percutaneous coronary interventions with or without stent implantation, and complications following cardiopulmonary bypass.


CRP is of definite value as an aid in early diagnosis of neonatal septicemia and bacterial meningitis and band neutrophil count as diagnostic parameters was in favour of CRP at this early stage of infection.

Acute-phase proteins and other systemic responses to inflammation.

A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation, and the mechanisms mediating them are becoming better understood.

C-reactive protein: a critical update.

Information is provided about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases, that identifies it as a possible therapeutic target.