C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction

@article{Griselli1999CReactivePA,
  title={C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction},
  author={Massimo Griselli and J. Herbert and W M Hutchinson and K. M. Taylor and Mohammed Ali Sohail and Thomas Krausz and Mark B Pepys},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={190},
  pages={1733 - 1740}
}
Myocardial infarction in humans provokes an acute phase response, and C-reactive protein (CRP), the classical acute phase plasma protein, is deposited together with complement within the infarct. The peak plasma CRP value is strongly associated with postinfarct morbidity and mortality. Human CRP binds to damaged cells and activates complement, but rat CRP does not activate complement. Here we show that injection of human CRP into rats after ligation of the coronary artery reproducibly enhanced… CONTINUE READING
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