C-Reactive Protein-Bound Enzymatically Modified Low-Density Lipoprotein Does Not Transform Macrophages into Foam Cells1

@article{Singh2008CReactivePE,
  title={C-Reactive Protein-Bound Enzymatically Modified Low-Density Lipoprotein Does Not Transform Macrophages into Foam Cells1},
  author={Sanjay K. Singh and M. V. Suresh and Deborah C Prayther and J. Moorman and A. Rusiñol and A. Agrawal},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={4316 - 4322}
}
The formation of low-density lipoprotein (LDL) cholesterol-loaded macrophage foam cells contributes to the development of atherosclerosis. C-reactive protein (CRP) binds to atherogenic forms of LDL, but the role of CRP in foam cell formation is unclear. In this study, we first explored the binding site on CRP for enzymatically modified LDL (E-LDL), a model of atherogenic LDL to which CRP binds. As reported previously, phosphocholine (PCh) inhibited CRP-E-LDL interaction, indicating the… Expand

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References

SHOWING 1-10 OF 63 REFERENCES
C-reactive protein binds to the 3beta-OH group of cholesterol in LDL particles.
Rat C-reactive protein causes a charge modification of LDL and stimulates its degradation by macrophages.
Interactions of C-reactive protein with low-density lipoproteins: implications for an active role of modified C-reactive protein in atherosclerosis.
...
1
2
3
4
5
...