• Corpus ID: 42395208

C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells.

@article{Basha2008CPhycocyaninIC,
  title={C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells.},
  author={Osama M. Basha and Raghda Abdel Latif Hafez and Yassin Mahmoud El-Ayouty and Karima Fathi Mahrous and Mohammed H Bareedy and Ahmed Mohamed Salama},
  journal={The Egyptian journal of immunology},
  year={2008},
  volume={15 2},
  pages={
          161-7
        }
}
C-Phycocyanin (C-Pc) is one of the major biliprotein pigments of unicellular cyanbacterium of Spirulina platenesis, it has nutritional, medicinal, and hepatoprotectant application. The growth and multiplication of human hepatoma cell lines (HepG2) under the effect of different concentrations of C-PC (0.8, 1.75, 3.5 and 7.0 microg/ml) against untreated cells as control for 24h were investigated. The results showed that the proliferating cells in presence of C-PC reached 70, 51, 44, and 39… 
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TLDR
It is demonstrated that C-PC induces apoptosis in K562 cells by cytochrome c release from mitochondria into the cytosol, PARP cleavage and down regulation of Bcl-2.
C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages.
TLDR
This C-PC induced apoptosis in RAW 264.7 cells appears to be mediated by the release of cytochrome c from mitochondria and independent of Bcl-2 expression, and may be due to reduced PGE(2) levels as a result of COX-2 inhibition.
Alteration of mitochondrial membrane potential by Spirulina platensis C‐phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular‐carcinoma cell line HepG2
TLDR
It is demonstrated that C‐PC induces apoptosis in R‐HepG2 cells and its potential as an anti‐HCC agent is demonstrated.
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TLDR
Pc reduced edema, histamine (Hi) release, myeloperoxidase (MPO) activity and the levels of prostaglandin (PGE(2)) and leukotriene (LTB(4)) in the inflamed tissues and showed neuroprotective effects in rat cerebellar granule cell cultures and in kainate-induced brain injury in rats.
Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae
TLDR
It is indicated that phycocyanin is able to scavenge OH• and RO• radicals, with activity equivalent to 0.125 mg/mL of dimethyl sulphoxide and trolox, specific scavengers of those radicals respectively.
C-Phycocyanin protects cerebellar granule cells from low potassium/serum deprivation-induced apoptosis
TLDR
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TLDR
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TLDR
Intraperitoneal administration of a single dose of phycocyanin to rats, one or three hours prior to R-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/ kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals.
C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro.
TLDR
It is demonstrated that phycocyanin is a potent peroxyl radical scavenger with an IC(50) of 5.0 microM and the rate constant ratios obtained for phydynamic acid and uric acid were 1.54 and 3.5, respectively, which clearly suggest that the covalently linked chromophore, phyCocyanobilin, is involved in the antioxidant and radical scavenging activity of phy cokyanin.
Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis.
TLDR
The present study points out that the hepatoprotective, anti-inflammatory, and anti-arthritic properties of phycocyanin reported in the literature may be due, in part, to its selective COX-2 inhibitory property, although its ability to efficiently scavenge free radicals and effectively inhibit lipid peroxidation may also be involved.
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