C-Met pathway promotes self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cell.

@article{Lim2014CMetPP,
  title={C-Met pathway promotes self-renewal and tumorigenecity of head and neck squamous cell carcinoma stem-like cell.},
  author={Young Chang Lim and Hyun Jung Kang and Jung Hwa Moon},
  journal={Oral oncology},
  year={2014},
  volume={50 7},
  pages={633-9}
}
OBJECTIVES Increasing evidence indicates that a rare subpopulation of cancer cells, namely, cancer stem cells (CSCs), is the primary cause of tumorigenesis in some tumor types, including head and neck squamous cell carcinoma (HNSCC). Hepatocyte growth factor (HGF) and its receptor, c-Met, are involved in tongue development and carcinogenesis of HNSCC. Here, we investigated whether activation of HGF/c-Met signaling influences the stem cell traits of HNSCC CSC. MATERIALS AND METHODS After HGF… CONTINUE READING
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