C-Met antisense oligodeoxynucleotide inhibits growth of glioma cells.

@article{Chu2006CMetAO,
  title={C-Met antisense oligodeoxynucleotide inhibits growth of glioma cells.},
  author={Shenghua Chu and Xianhou Yuan and Zhiqiang Li and Pucha Jiang and Jie Ming Zhang},
  journal={Surgical neurology},
  year={2006},
  volume={65 6},
  pages={533-8; discussion 538}
}
BACKGROUND C-Met, a receptor tyrosine kinase, and its ligand, hepatocyte growth factor, are critical in cellular proliferation, motility, and invasion and are known to be overexpressed in gliomas. The aim of our study was therefore to investigate the effect of transfected caroboxyfluorescein-5-succimidyl ester (FAM)-labeled c-Met antisense oligonucleotide (ASODN) on growth of glioma cells. METHODS Conjugated FAM-labeled c-Met ASODN was encapsulated by LIPOFECTAMINE PLUS Reagent and then added… CONTINUE READING
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