C-H Amination of Purine Derivatives via Radical Oxidative Coupling.

@article{Luo2018CHAO,
  title={C-H Amination of Purine Derivatives via Radical Oxidative Coupling.},
  author={Zheng Luo and Ziyang Jiang and Wei Jiang and Dongen Lin},
  journal={The Journal of organic chemistry},
  year={2018},
  volume={83 7},
  pages={
          3710-3718
        }
}
An oxidative coupling reaction between purines and alkyl ethers/benzyl compounds was developed to synthesize a series of N9 alkylated purine derivatives using n-Bu4NI as a catalyst and t-BuOOH as an oxidant. This protocol uses commercially available, inexpensive catalysts and oxidants and has a wide range of substrates with a simple operation.