C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.


Glycogen phosphorylase inhibitors are considered as potential antidiabetic agents. 3-(β-d-Glucopyranosyl)-5-substituted-1,2,4-triazoles were prepared by acylation of O-perbenzoylated N (1)-tosyl-C-β-d-glucopyranosyl formamidrazone and subsequent removal of the protecting groups. The best inhibitor was 3-(β-d-glucopyranosyl)-5-(2-naphthyl)-1,2,4-triazole (K i = 0.41 μM against rabbit muscle glycogen phosphorylase b).

DOI: 10.1021/ml4001529

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@article{Bokor2013CGlucopyranosyl124triazolesAN, title={C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.}, author={{\'E}va Bokor and Tibor Docsa and P{\'a}l Gergely and L{\'a}szl{\'o} Soms{\'a}k}, journal={ACS medicinal chemistry letters}, year={2013}, volume={4 7}, pages={612-5} }